DNA vs mRNA vaccines
While generally well-tolerated, DNA vaccines may still carry other risks. Risk of insertional mutagenesis, while possible, appears low as no significant DNA vaccine integration into genomic DNA has yet been shown.
The biggest risks related to DNA vaccines remain relating to genotoxicity and auto-immunity. Arguably the most important instance of anti-DNA immunity is as a hallmark of systemic lupus erythematosus (SLE), an autoimmune disease [241]
RNA vaccines have been generally safe in humans, although unintended adverse reactions are the biggest fear for RNA vaccines.
source: Advances in gene-based vaccine platforms to address the COVID-19 pandemic